"The Rune Drive Gambit" is a Starfinder RPG adventure for four 5th-level characters by Larry Wilhelm. The adventure concludes the "Against the Aeon Throne" Adventure Path, a 3-part, monthly campaign in which players visit and explore some of the worlds of the sinister Azlanti Star Empire. It also includes advice for how to continue the campaign, a detailed exploration of the peacekeeping organization known as the Stewards, and a selection of new monsters from alien worlds.